Antioxidant properties of 1,2,3,4,6-penta-O-galloyl-β-D-glucose from Elaeocarpus sylvestris var. ellipticus

被引：35

作者：

Piao, Mei Jing ^{[1
]}

Kang, Kyoung Ah ^{[1
]}

Zhang, Rui ^{[1
]}

Ko, Dong Ok ^{[1
]}

Wang, Zhi Hong ^{[1
]}

Lee, Keun Hwa ^{[1
]}

Chang, Weon Young ^{[1
]}

Chae, Sungwook ^{[2
]}

Jee, Youngheun ^{[3
]}

Shin, Taekyun ^{[3
]}

Park, Jae Woo ^{[4
]}

Lee, Nam Ho ^{[5
]}

Hyun, Jin Won ^{[1
]}

机构：

[1] Cheju Natl Univ, Sch Med, Jeju Si 690756, South Korea

[2] Korea Inst Oriental Med, Dept Herbal Resources Res, Taejon 305811, South Korea

[3] Cheju Natl Univ, Dept Vet Med, Jeju Si 690756, South Korea

[4] Cheju Natl Univ, Dept Nucl & Energy Engn, Jeju Si 690756, South Korea

[5] Cheju Natl Univ, Dept Chem, Coll Nat Sci, Jeju Si 690756, South Korea

来源：

FOOD CHEMISTRY | 2009年 / 115卷 / 02期

关键词：

Elaeocarpus sylvestris var. ellipticus; Antioxidant; 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose (PGG); Antioxidant enzyme; CHINESE MEDICINAL-PLANTS; GLUTATHIONE-PEROXIDASE; MITOCHONDRIAL CONTROL; SUPEROXIDE-DISMUTASE; PHENOLIC-COMPOUNDS; HEME OXYGENASE-1; ELLAGIC ACID; ASSAY; CELLS; EXPRESSION;

D O I：

10.1016/j.foodchem.2008.12.020

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The antioxidant potential of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), isolated from Elaeocarpus sylvestris var. ellipticus, was investigated by various established systems based on cell-free and cell system experiments, such as radical detection, antioxidant enzyme assay, lipid peroxidation detection, and cell viability assay. PGG was found to quench the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and intracellular reactive oxygen species. PGG recovered the cellular antioxidant enzyme activities of superoxide dismutase, catalase, and glutathione peroxidase, which were reduced by H2O2 treatment, thereby resulting in the inhibition of lipid peroxidation. Cytoprotective effects of PGG were based on the results of DNA fragmentation, mitochondrial membrane potential (Delta psi), apoptotic body formation, and caspase-3 activity. The results suggest that PGG protects cells against H2O2-induced cell damage via antioxidant properties. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：412 / 418

页数：7

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