Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells

被引：36

作者：

Bischof, Joachim ^{[1
]}

Westhoff, Mike-Andrew ^{[2
]}

Wagner, Johanna Elisabeth ^{[3
]}

Halatsch, Marc-Eric ^{[3
]}

Trentmann, Stephanie ^{[1
]}

Knippschild, Uwe ^{[1
]}

Wirtz, Christian Rainer ^{[2
,3
]}

Burster, Timo ^{[3
]}

机构：

[1] Ulm Univ, Surg Ctr, Med Ctr, Dept Gen & Visceral Surg, Ulm, Germany

[2] Ulm Univ, Med Ctr, Dept Pediat & Adolescent Med, Ulm, Germany

[3] Ulm Univ, Med Ctr, Surg Ctr, Dept Neurosurg, Albert Einstein Allee 23, D-89081 Ulm, Germany

来源：

TUMOR BIOLOGY | 2017年 / 39卷 / 03期

关键词：

Major histocompatibility complex class I; cathepsin; glioblastoma; autophagy; MHC CLASS-I; LYSOSOMAL PROTEIN-DEGRADATION; ACUTE MYELOID-LEUKEMIA; PROSPECTIVE IDENTIFICATION; GLIOMA PROGRESSION; MALIGNANT GLIOMAS; SIDE POPULATION; GENE-EXPRESSION; TUMOR INVASION; S EXPRESSION;

D O I：

10.1177/1010428317692227

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One major obstacle in cancer therapy is chemoresistance leading to tumor recurrence and metastasis. Cancer stem cells, in particular glioblastoma stem cells, are highly resistant to chemotherapy, radiation, and immune recognition. In case of immune recognition, several survival mechanisms including, regulation of autophagy, proteases, and cell surface major histocompatibility complex class I molecules, are found in glioblastoma stem cells. In different pathways, cathepsins play a crucial role in processing functional proteins that are necessary for several processes and proper cell function. Consequently, strategies targeting these pathways in glioblastoma stem cells are promising approaches to interfere with tumor cell survival and will be discussed in this review.

引用

页码：1 / 13

页数：13

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