Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases

被引：13
|
作者：
Xu, Xingyun [1 ,2 ]
Miao, Zhigang [2 ]
Sun, Miao [1 ]
Wan, Bo [2 ]
机构：
[1] Soochow Univ, Affiliated Hosp 1, Inst Fetol, Suzhou, Peoples R China
[2] Soochow Univ, Inst Neurosci, Suzhou, Peoples R China
来源：
INTERNATIONAL JOURNAL OF GENOMICS | 2021年 / 2021卷
基金：
国家重点研发计划; 美国国家科学基金会;
关键词：
D O I：
10.1155/2021/6632719
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The major biological function of the sperm cell is to transmit the paternal genetic and epigenetic information to the embryo as well as the following offspring. Sperm has a unique epigenome. An increasing body of epidemiological study supports that paternal stress induced by environmental exposures and lifestyle can modulate the sperm epigenome (including histone modification, DNA methylation, and noncoding RNA expression), sperm-egg fusion, embryo development, and offspring health. Based on the existing literature, we have summarized the paternal exposure on sperm epigenome along with the representative phenotypes of offspring and the possible mechanism involved.
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页数：10
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