Life history trade-offs in cancer evolution

被引：153
|
作者：
Aktipis, C. Athena [1 ,2 ,3 ]
Boddy, Amy M. [1 ,2 ]
Gatenby, Robert A. [4 ]
Brown, Joel S. [5 ]
Maley, Carlo C. [1 ,2 ]
机构：
[1] Univ Calif San Francisco, Ctr Evolut & Canc, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA
[3] Arizona State Univ, Dept Psychol, Tempe, AZ 85287 USA
[4] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
[5] Univ Illinois, Dept Biol Sci, Chicago, IL 60607 USA
来源：
NATURE REVIEWS CANCER | 2013年 / 13卷 / 12期
基金：
美国国家卫生研究院;
关键词：
ACUTE MYELOID-LEUKEMIA; STEM-CELLS; NATURAL-SELECTION; SUPPRESSOR-CELLS; CLONAL EVOLUTION; BREAST-CANCER; R-SELECTION; TUMOR; HETEROGENEITY; INFLAMMATION;
D O I：
10.1038/nrc3606
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Somatic evolution during cancer progression and therapy results in tumour cells that show a wide range of phenotypes, which include rapid proliferation and quiescence. Evolutionary life history theory may help us to understand the diversity of these phenotypes. Fast life history organisms reproduce rapidly, whereas those with slow life histories show less fecundity and invest more resources in survival. Life history theory also provides an evolutionary framework for phenotypic plasticity, which has potential implications for understanding 'cancer stem cells'. Life history theory suggests that different therapy dosing schedules might select for fast or slow life history cell phenotypes, with important clinical consequences.
引用
收藏
页码：883 / 892
页数：10
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