Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands

被引：12

作者：

Wu, WL ^{[1
]}

Caplen, MA ^{[1
]}

Domalski, MS ^{[1
]}

Zhang, HT ^{[1
]}

Fawzi, A ^{[1
]}

Burnett, DA ^{[1
]}

机构：

[1] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(02)00652-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of aminoalkylazetidines has been discovered as novel ORL1 receptor ligands. Structure-activity relationships have been investigated at the azetidine N and the alkyl side chain sites. Several potent and selective analogues have been identified. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3157 / 3160

页数：4

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