Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands

被引：12
|
作者：
Wu, WL [1 ]
Caplen, MA [1 ]
Domalski, MS [1 ]
Zhang, HT [1 ]
Fawzi, A [1 ]
Burnett, DA [1 ]
机构：
[1] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 21期
关键词：
D O I：
10.1016/S0960-894X(02)00652-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of aminoalkylazetidines has been discovered as novel ORL1 receptor ligands. Structure-activity relationships have been investigated at the azetidine N and the alkyl side chain sites. Several potent and selective analogues have been identified. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3157 / 3160
页数：4
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