Synthesis of Imidazo[1,5-a]quinolines via Metal-Free Oxidative Amination of sp3 C-H Bonds

被引：9

作者：

Liu, Huanhuan ^{[1
]}

Wang, Xinfeng ^{[1
]}

Ma, Chen ^{[1
,2
]}

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China

[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2018年 / 50卷 / 14期

基金：

中国国家自然科学基金;

关键词：

quinolone; amino acid; metal-free; oxidative amination; C-H functionalization; EFFICIENT SYNTHESIS; HIGHLY POTENT; DERIVATIVES; LIGANDS; DESIGN; AMINES;

D O I：

10.1055/s-0037-1610137

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel oxidative amination of sp(3) C-H bonds was developed for the efficient synthesis of imidazo[1,5-a]quinolines from readily available -amino acids and (2-azaaryl)methanes. This domino protocol, which was established in a TBAI-TBHP oxidation system, includes transition-metal-free decarboxylation and intramolecular cyclization. This method represented a new avenue for the synthesis of N-heterocycles using 2-methylquinolines as the synthon of quinoline-2-carbaldehydes.

引用

页码：2761 / 2767

页数：7

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