Synthesis of New 4-(tert-Octyl)phenol Derivatives and Their Anticancer Activity against Human Prostate and Lung Cancer Cell Lines

被引：3
|
作者：
Che, Haiyan [1 ]
Fang, Yuanying [1 ]
Gurung, Santosh K. [1 ]
Luo, Jun [1 ]
Yoon, Deok Hyo [2 ]
Sung, Gi-Ho [3 ]
Kim, Tae Woong [2 ]
Park, Haeil [1 ]
机构：
[1] Kangwon Natl Univ, Coll Pharm, Chunchon 200701, South Korea
[2] Kangwon Natl Univ, Coll Nat Sci Biochem, Chunchon 200701, South Korea
[3] Rural Dev Adm, Suwon 441707, South Korea
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2014年 / 35卷 / 07期
关键词：
Cordyceps militaris; Militarin; 4-(tert-Octyl)phenol derivatives; D-Mannitol substructure; Anticancer activity; CORDYCEPS-MILITARIS; 3'-DEOXYADENOSINE;
D O I：
10.5012/bkcs.2014.35.7.2038
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
4-(tert-Octyl)phenol derivative bearing, the D-mannitol substructure (6a, 6b, 7) were prepared from D-mannitol and evaluated their anticancer activity against human lung (A549) and prostate (Lncap, Du145, PC3) cancer cell lines. Among derivatives tested, the bis(tert-octyl)phenoxy compound 7 exhibited strongest proliferation inhibitory activities against human cancer cell lines tested, especially high sensitivity to human Du145 prostate cancer cells (IC50 = 7.3 mu M).
引用
收藏
页码：2038 / 2042
页数：5
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