SYNTHESIS OF DIHYDROOXEPINS BY THE CYCLOADDITION OF 2-AMINO-4,5-DIHYDRO-3-FURANCARBONITRILES WITH DIMETHYL ACETYLENEDICARBOXYLATE

被引：0

作者：

Okabe, Fumi ^{[1
]}

Maruoka, Hiroshi ^{[1
]}

Masumoto, Eiichi ^{[1
]}

Fujioka, Toshihiro ^{[1
]}

Yamagata, Kenji ^{[1
]}

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Jonan Ku, Fukuoka 8140180, Japan

来源：

HETEROCYCLES | 2013年 / 87卷 / 11期

关键词：

BETA-ENAMINO ESTERS; HETEROCYCLIC ENAMINONITRILES; STRUCTURAL ELUCIDATION; CIGUATOXIN; TRITERPENOIDS; ZOAPATANOL; CHEMISTRY; SPONGE;

D O I：

10.3987/COM-13-12819

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and efficient synthesis of dihydrooxepins is described. Treatment of readily available 2-amino-4,5-dihydro-3-furancarbonitriles with dimethyl acetylenedicarboxylate at room temperature caused smoothly a cycloaddition reaction, followed by a ring expansion, giving the corresponding dihydrooxepin derivatives.

引用

页码：2361 / 2368

页数：8

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