Total synthesis of siomycin A

被引：19

作者：

Mori, Tomonori ^{[1
]}

Higashibayashi, Shuhei ^{[1
]}

Goto, Taiji ^{[1
]}

Kohno, Mitsunori ^{[1
]}

Satouchi, Yukiko ^{[1
]}

Shinko, Kazuyuki ^{[1
]}

Suzuki, Kengo ^{[1
]}

Suzuki, Shunya ^{[1
]}

Tohmiya, Hiraku ^{[1
]}

Hashimoto, Kimiko ^{[1
]}

Nakata, Masaya ^{[1
]}

机构：

[1] Keio Univ, Fac Sci & Technol, Dept Appl Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 08期

关键词：

siomycin A; one-pot cyclization-elongation; thiazoline; dehydroamino acid;

D O I：

10.1016/j.tetlet.2006.12.121

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have succeeded in the total synthesis of siomycin A, a representative compound of the thiostrepton family of peptide antibiotics, featuring the one-pot cyclization-elongation of our strategic intermediates and the late-stage formations of the thiazoline and dehydroamino acid moieties. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1331 / 1335

页数：5

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