Vaccinia virus A35R inhibits MHC class II antigen presentation

被引：30

作者：

Rehm, Kristina E. ^{[1
]}

Connor, Ramsey F. ^{[1
]}

Jones, Gwendolyn J. B. ^{[1
]}

Yimbu, Kenneth ^{[1
]}

Roper, Rachel L. ^{[1
]}

机构：

[1] E Carolina Univ, Brody Sch Med, Dept Microbiol & Immunol, Greenville, NC 27834 USA

来源：

VIROLOGY | 2010年 / 397卷 / 01期

关键词：

Poxvirus; Vaccinia; Macrophage; Antigen presentation; Cytokine; Apoptosis; MHC; HUMAN DENDRITIC CELLS; SMALLPOX VACCINATION; NITRIC-OXIDE; T-CELLS; INFECTION; POXVIRUS; PROTEIN; VIRULENCE; EXPRESSION; MATURATION;

D O I：

10.1016/j.virol.2009.11.008

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Vaccinia virus gene A35R (Copenhagen designation) is highly conserved in mammalian-tropic poxviruses and is an important virulence factor, but its function was unknown. We show herein that A35 does not affect viral infectivity, apoptosis induction, or replication; however, we found that A35 significantly inhibited MHC class II-restricted antigen presentation, immune priming of T lymphocytes, and subsequent chemokine and cytokine synthesis. A35 localized to endosomes and reduced the amount of a model antigenic peptide displayed in the cleft of class II MHC. In addition, A35 decreased VV specific T cell responses in vivo. Thus, this is the first report identifying a function for the A35 protein in virulence as well as the first report identifying a VV gene that inhibits peptide antigen presentation. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：176 / 186

页数：11

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