Toxicodynamics and long-term toxicity of the recreational drug, 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy')

被引：81
|
作者：
Ricaurte, GA
McCann, UD
Szabo, Z
Scheffel, U
机构：
[1] Johns Hopkins Med Inst, Dept Neurol, Baltimore, MD 21224 USA
[2] Johns Hopkins Med Inst, Dept Psychiat, Baltimore, MD 21224 USA
[3] Johns Hopkins Med Inst, Dept Radiol, Baltimore, MD 21224 USA
来源：
TOXICOLOGY LETTERS | 2000年 / 112卷
关键词：
serotonin; neurotoxicity; amphetamines; PET; transporters; 3,4-methylenedioxy-methamphetamine;
D O I：
10.1016/S0378-4274(99)00216-7
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
The recreational drug, (+/-)3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), is a potent serotonin (5-HT) neurotoxin in animals. Whether humans who use MDMA incur 5-HT neural injury is unknown. The present studies utilized positron emission tomography (PET) in conjunction with the 5-HT transporter ligand, [C-11]McN-5652 to assess the status of brain 5-HT neurons in human MDMA users. Like nonhuman primates treated with neurotoxic doses of MDMA, humans with a history of MDMA use showed lasting decrements in global brain [C-11]McN-5652 binding, with decreases in [C-11]McN-5652 binding positively correlated to the extent of previous MDMA use. These results suggest that human MDMA use results in brain 5-HT neurotoxicity. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：143 / 146
页数：4
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