Glucose as an Eco-Friendly Reductant in a One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

被引：12
|
作者：
dos Santos, Thiago [1 ,2 ]
Grundke, Caroline [1 ]
Lucas, Tobias [1 ]
Grossmann, Luca [1 ]
Clososki, Giuliano Cesar [2 ]
Opatz, Till [1 ]
机构：
[1] Johannes Gutenberg Univ Mainz, Dept Chem, D-55128 Mainz, Germany
[2] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Biomol Sci, Ave Cafe S-N, BR-14040900 Ribeirao Preto, SP, Brazil
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 41期
基金：
巴西圣保罗研究基金会;
关键词：
Biomass; Carbohydrates; Dihydroquinazolinones; One-pot reactions; Reduction; HIGHLY ENANTIOSELECTIVE SYNTHESIS; AROMATIC NITRO-COMPOUNDS; MEDIATED SYNTHESIS; METAL-FREE; ACID; QUINAZOLINONES; HYDROGENATION; EFFICIENT; CATALYST; ARYLHYDROXYLAMINES;
D O I：
10.1002/ejoc.202000970
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Carbohydrates such as glucose are an abundant renewable resource that can be employed in synthetic processes as a source of carbon and/or hydrogen to yield products of high economical and biological impact. Herein, we report a versatile and environmentally friendly protocol for the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones, a privileged scaffold in medicinal chemistry, based on the use of glucose as an eco-friendly reductant in alkaline aqueous medium. This method can be viewed as a blueprint for the development of further one-pot sequences involving glucose as a reductant.
引用
收藏
页码：6429 / 6432
页数：4
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