Suppression of P50 evoked potential component, schizotypal beliefs and smoking

被引:39
|
作者
Croft, RJ [1 ]
Dimoska, A
Gonsalvez, CJ
Clarke, AR
机构
[1] Swinburne Univ Technol, Brain Sci Inst, Melbourne, Vic 3122, Australia
[2] Univ Wollongong, Brain & Behav Res Inst, Wollongong, NSW 2522, Australia
关键词
P50; event-related potentials; sensory gating; schizophrenia; schizotypy; unreality;
D O I
10.1016/j.psychres.2004.05.009
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Suppression of the P50 component of the evoked potential is an electrophysiological index of sensory gating that is blunted in schizophrenia spectrum disorders. Although P50 suppression is thought to be related to symptomatology, this is yet to be shown. The failure to demonstrate this relation has led some to argue that P50 suppression and symptomatology are not related. However, a possible confound has recently been corroborated i.e., chronic smoking is related to superior P50 suppression [Crawford et al., Neuroscience Letters 317 (2002) 151]}, and a relation has been found in questionnaire-defined individuals with indications of schizotypy {i.e.,., psychometric schizotypy is related to poor P50 suppression [Croft et al., Biological Psychiatry, 50 (2001) 441]}. The present study attempted to replicate and extend both studies by examining P50 suppression, smoking histories, psychometric schizotypy and NEO Five-Factor Inventory (NEON) scores in 37 healthy participants. Replicating Crawford et al., P50 suppression was better in the heavier smokers. Providing a partial replication of Croft et al., P50 suppression was inversely related to schizotypy scores in participants who smoked little or not at all; however, P50 suppression was positively related to schizotypy in heavier smokers. Covarying for age and NEON scale scores had little effect on these relations. The findings provide evidence of important confounds that would limit our ability to detect P50 suppression/symptom relations in schizophrenia. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:53 / 62
页数:10
相关论文
共 50 条
  • [31] Affect modulation of the P50 ERP component
    Hamilton, RA
    Carroll, CA
    Hetrick, WP
    PSYCHOPHYSIOLOGY, 2002, 39 : S40 - S40
  • [32] Gating of auditory and somatosensory evoked potential P50 and the correlation to skin conductance response
    Arnfred, SM
    Eder, DN
    Chen, ACN
    Glenthoj, B
    Hemmingsen, R
    INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 2000, 35 (01) : 49 - 49
  • [33] P50 AUDITORY-EVOKED POTENTIALS IN EPILEPSY
    DRAKE, ME
    WEATE, SJ
    ANDREWS, JM
    CASTLEBERRY, CJ
    JOURNAL OF EPILEPSY, 1995, 8 (03): : 197 - 200
  • [34] The P50 auditory evoked potential in violent and non-violent patients with schizophrenia
    Fresan, Ana
    Apiquian, Rogelio
    Garcia-Anaya, Maria
    de la Fuente-Sandoval, Camilo
    Nicolini, Humberto
    Graff-Guerrero, Ariel
    SCHIZOPHRENIA RESEARCH, 2007, 97 (1-3) : 128 - 136
  • [35] Effects of anxiety on P50 subcomponents of the auditory evoked potential in normalcontrols and patients with schizophrenia
    Erwin, RJ
    Beenken, B
    Keedy, SK
    Marlow, M
    Polk, S
    Turetsky, B
    Gur, RE
    BIOLOGICAL PSYCHIATRY, 2003, 53 (08) : 27S - 28S
  • [36] Affect modulation of the auditory P50 evoked response
    Carroll, CA
    Hamilton, RA
    Hetrick, WP
    PSYCHOPHYSIOLOGY, 2003, 40 : S31 - S31
  • [37] Inhibition of P50 auditory evoked potentials in schizophrenia
    Freedman, R
    Adler, LE
    Olincy, A
    Leonard, S
    INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 1999, 33 (01) : 53 - 54
  • [38] P50 evoked response dishabituation with stimulus change
    Boutros, NN
    JOURNAL OF COGNITIVE NEUROSCIENCE, 1998, 10 : 38 - 38
  • [39] Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorder
    Cadenhead, KS
    Light, GA
    Geyer, MA
    Braff, DL
    AMERICAN JOURNAL OF PSYCHIATRY, 2000, 157 (01): : 55 - 59
  • [40] P50 Sensory Gating and Smoking in the General Population
    Brinkmeyer, Juergen
    Mobascher, Arian
    Musso, Francesco
    Wagner, Michael
    Frommann, Ingo
    Gruender, Gerd
    Spreckelmeyer, Katja
    Wienker, Thomas
    Diaz-Lacava, Amalia
    Holler, Daniela
    Dahmen, Norbert
    Thuerauf, Norbert
    Clepce, Marion
    Kiefer, Falk
    de Millas, Walter
    Gallinat, Juergen
    Winterer, Georg
    BIOLOGICAL PSYCHIATRY, 2011, 69 (09) : 258S - 258S