Small Molecule Inhibitors of AKT/PKB Kinase as a Strategy for Treating Cancer

被引:14
|
作者
Heerding, Dirk A. [1 ]
Safonov, Igor G. [1 ]
Verma, Sharad K. [1 ]
机构
[1] GlaxoSmithKline Inc, Collegeville, PA 19426 USA
关键词
D O I
10.1016/S0065-7743(07)42023-1
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:365 / 376
页数:12
相关论文
共 50 条
  • [31] Small molecule tyrosine kinase inhibitors in glioblastoma
    Kim, Gayoung
    Ko, Young Tag
    ARCHIVES OF PHARMACAL RESEARCH, 2020, 43 (04) : 385 - 394
  • [32] Targeting of the Akt/PKB kinase to the actin skeleton
    V. Cenni
    A. Sirri
    M. Riccio
    G. Lattanzi
    S. Santi
    A. de Pol
    N. M. Maraldi
    S. Marmiroli
    Cellular and Molecular Life Sciences CMLS, 2003, 60 : 2710 - 2720
  • [33] Targeting of the Akt/PKB kinase to the actin skeleton
    Cenni, V
    Sirri, A
    Riccio, M
    Lattanzi, G
    Santi, S
    de Pol, A
    Maraldi, NM
    Marmiroli, S
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2003, 60 (12) : 2710 - 2720
  • [34] Characterization of small molecule inhibitors of PELP1 for treating advanced breast cancer
    Altwegg, Kristin Ann
    Viswanadhapalli, Suryavathi
    Mann, Monica
    Pratap, Uday P.
    Li, Mengxing
    Liu, Junhao
    Luo, Yiliao
    Sareddy, Gangadhara R.
    Vankayalapati, Hariprasad
    Vadlamudi, Ratna K.
    CANCER RESEARCH, 2020, 80 (16)
  • [35] The complexity of protein kinase B (PKB/Akt) signaling - implications for human cancer
    Yang, ZZ
    Hemmings, BA
    PROTEIN MODULES IN CELLULAR SIGNALLING, 2001, 318 : 29 - 40
  • [36] A small molecule–kinase interaction map for clinical kinase inhibitors
    Miles A Fabian
    William H Biggs
    Daniel K Treiber
    Corey E Atteridge
    Mihai D Azimioara
    Michael G Benedetti
    Todd A Carter
    Pietro Ciceri
    Philip T Edeen
    Mark Floyd
    Julia M Ford
    Margaret Galvin
    Jay L Gerlach
    Robert M Grotzfeld
    Sanna Herrgard
    Darren E Insko
    Michael A Insko
    Andiliy G Lai
    Jean-Michel Lélias
    Shamal A Mehta
    Zdravko V Milanov
    Anne Marie Velasco
    Lisa M Wodicka
    Hitesh K Patel
    Patrick P Zarrinkar
    David J Lockhart
    Nature Biotechnology, 2005, 23 : 329 - 336
  • [37] New targets for therapy in breast cancer: Small molecule tyrosine kinase inhibitors
    Nancy U Lin
    Eric P Winer
    Breast Cancer Research, 6
  • [38] Small molecule tyrosine kinase inhibitors and pancreatic cancer-Trials and troubles
    Lakkakula, Bhaskar Venkata Kameswara Subrahmanya
    Farran, Batoul
    Lakkakula, Saikrishna
    Peela, Sujatha
    Yarla, Nagendra Sastry
    Bramhachari, Pallaval Veera
    Kamal, Mohammad Amjad
    Saddala, Madhu Sudhana
    Nagaraju, Ganji Purnachandra
    SEMINARS IN CANCER BIOLOGY, 2019, 56 : 149 - 167
  • [39] Editorial: Exploring novel approaches to small molecule kinase inhibitors in cancer treatment
    Carbone, Anna
    Counago, Rafael M.
    Salas, Cristian O.
    Moltalbano, Alessandra
    FRONTIERS IN CHEMISTRY, 2025, 13
  • [40] New targets for therapy in breast cancer - Small molecule tyrosine kinase inhibitors
    Lin, NU
    Winer, EP
    BREAST CANCER RESEARCH, 2004, 6 (05) : 204 - 210