Modular Peptide Growth Factors for Substrate-Mediated Stem Cell Differentiation

被引：40
|
作者：
Lee, Jae Sam [1 ]
Lee, Jae Sung [1 ]
Wagoner-Johnson, Amy [2 ]
Murphy, William L. [1 ]
机构：
[1] Univ Wisconsin, Dept Biomed Engn, Madison, WI 53706 USA
[2] Univ Illinois, Dept Mech Sci & Engn, Urbana, IL 61801 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 34期
关键词：
biomineralization; hydroxyapatite; osteocalcin; osteogenesis; protein modifications; BONE; HYDROXYAPATITE; PROTEIN; REPAIR;
D O I：
10.1002/anie.200901618
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The sequence specificity of the binding of a modular peptide growth factor (eBGa3) that contains a BMP2-derived sequence and a mineral-binding sequence inspired by osteocalcin to calcium ions of hydroxyapatite (HA) may be attributed in part to evolution of an α-helical structure in the presence of HA, which allows for registration of γ-carboxylated glutamic acid residues in the peptide (cyan) with calcium atoms (orange) in the HA crystal lattice. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：6266 / 6269
页数：4
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