Palladium-Catalyzed Synthesis of (Hetero)Aryl Alkyl Sulfones from (Hetero)Aryl Boronic Acids, Unactivated Alkyl Halides, and Potassium Metabisulfite

被引：181

作者：

Shavnya, Andre ^{[1
]}

Hesp, Kevin D. ^{[1
]}

Mascitti, Vincent ^{[1
]}

Smith, Aaron C. ^{[1
]}

机构：

[1] Pfizer Inc, Worldwide Med Chem, Groton, CT 06340 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 46期

关键词：

alkylation; boronic acids; homogeneous catalysis; palladium; sulfones; SULFUR-DIOXIDE; ARYL SULFONES; SELECTIVE OXIDATION; HYDROGEN-PEROXIDE; SULFIDES; DERIVATIVES; COMPLEXES; EFFICIENT; INSERTION; SULFONYLATION;

D O I：

10.1002/anie.201505918

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium-catalyzed one-step synthesis of (hetero)aryl alkyl sulfones from (hetero)arylboronic acids, potassium metabisulfite, and unactivated or activated alkylhalides is described. This transformation is of broad scope, occurs under mild conditions, and employs readily available reactants. A stoichiometric experiment has led to the isolation of a catalytically active dimeric palladium sulfinate complex, which was characterized by X-ray diffraction analysis.

引用

页码：13571 / 13575

页数：5

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