Novel, base-promoted reaction of N-alkoxycarbonyl-O-(halosubstituted 4-nitrophenyl)-hydroxylamines

被引：1

作者：

Boyles, DC ^{[1
]}

Curran, TT ^{[1
]}

Greene, D ^{[1
]}

Macikenas, D ^{[1
]}

Parlett, RV ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Pharmaceut Sci, Ann Arbor, MI 48105 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(02)01536-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper describes base-promoted reactions of N-alkoxycarbonyl-O-(nitrophenyl)hydroxylamines which contain a halogen attached to the aromatic ring. The reaction is promoted under mild conditions (NaHCO3, or K2CO3) and provides the N-alkoxycarbonyl-N-hydroxyaniline. In a crossover experiment, some scrambling was observed which suggests that the reaction is inter- and intramolecular in nature. N-Boc-(2,6-di-Cl-4-NO2-phenyl)hydroxylamine was also found to N-Boc aminate Bn2NH to form the protected hydrazine in modest yield. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：6735 / 6737

页数：3

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