Novel, base-promoted reaction of N-alkoxycarbonyl-O-(halosubstituted 4-nitrophenyl)-hydroxylamines

被引：1
|
作者：
Boyles, DC [1 ]
Curran, TT [1 ]
Greene, D [1 ]
Macikenas, D [1 ]
Parlett, RV [1 ]
机构：
[1] Pfizer Global Res & Dev, Pharmaceut Sci, Ann Arbor, MI 48105 USA
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 38期
关键词：
D O I：
10.1016/S0040-4039(02)01536-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This paper describes base-promoted reactions of N-alkoxycarbonyl-O-(nitrophenyl)hydroxylamines which contain a halogen attached to the aromatic ring. The reaction is promoted under mild conditions (NaHCO3, or K2CO3) and provides the N-alkoxycarbonyl-N-hydroxyaniline. In a crossover experiment, some scrambling was observed which suggests that the reaction is inter- and intramolecular in nature. N-Boc-(2,6-di-Cl-4-NO2-phenyl)hydroxylamine was also found to N-Boc aminate Bn2NH to form the protected hydrazine in modest yield. (C) 2002 Elsevier Science Ltd. All rights reserved.
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收藏
页码：6735 / 6737
页数：3
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