Intracellular changes in rat hepatocytes after intratracheal administration of highly dispersed silicon dioxide and uridine effects on these changes

被引：3
|
作者：
Lebkova, N. P. [1 ]
Baranov, V. I. [1 ]
机构：
[1] Russian State Med Acad Postgrad Educ, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2006年 / 141卷 / 05期
关键词：
silicon dioxide; hepatocytes; uridine; electron microscopy;
D O I：
10.1007/s10517-006-0244-7
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Rat hepatocytes were examined under electron microscope at early terms after intratracheal administration of highly dispersed silicon dioxide powder against the background of uridine treatment. Penetration of powder particles into hepatocyte cytoplasm, nuclei, mitochondria, and peroxisomes and development of bacteria in these cells were observed. Uridine reduced the destructive effect of powder on the organelles, increased glycogen content in hepatocytes, and inhibited the formation of capsulated bacterial forms in these cells.
引用
收藏
页码：653 / 656
页数：4
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