B-cell lymphoma 2 rs17757541 C>G polymorphism was associated with an increased risk of coronary artery disease in a Chinese population

被引：1
|
作者：
Xuan, Yang [1 ]
Wang, Li-Na [1 ,2 ]
Wei, Ping-Min [1 ]
Zhi, Hong [3 ]
Lu, Zu-Hong [2 ]
机构：
[1] Southeast Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Minist Educ,Key Lab Environm Med Engn, Nanjing 210009, Jiangsu, Peoples R China
[2] Southeast Univ, Sch Biol Sci & Med Engn, Nanjing 210009, Jiangsu, Peoples R China
[3] Southeast Univ, Zhongda Hosp, Dept Cardiol, Nanjing 210009, Jiangsu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 11期
基金：
中国国家自然科学基金;
关键词：
BCL2; polymorphism; coronary artery disease; molecular epidemiology; apoptosis; VASCULAR APOPTOSIS; BCL-2; FAMILY; CELL; ATHEROSCLEROSIS; ACTIVATION; CANCER; PROLIFERATION; RECEPTOR; GENE;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The goal of our study was to evaluate the genetic effects of sixteen single nucleotide polymorphisms (SNPs) in apoptosis-related genes on the development of coronary artery disease (CAD) through a case-control study. A total of 1979 individuals, including 826 CAD cases (aged 67.27 +/- 10.26 years) and 1153 non-CAD controls (aged 59.13 +/- 10.51 years), were enrolled into the study. The genotypes were determined using a custom-by-design 48-Plex SNPscanTM Kit. The results showed that the BCL2 rs17757541 C>G polymorphism was associated with increased risk of CAD in homozygote comparison and recessive genetic model. However, no association between the other fifteen SNPs and CAD risk was observed. Stratified analyses indicated a significantly increased risk of CAD associated with the BCL2 rs17757541 C>G polymorphism among males and younger patients. Therefore, the results indicated that there is a close correlation between the BCL2 rs17757541 C>G polymorphism and CAD, which suggests that this SNP site should be further studied as a potential biomarker for CAD.
引用
收藏
页码：15147 / 15154
页数：8
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