Synthesis of 3-Amino-8-azachromans and 3-Amino-7-azabenzofurans via Inverse Electron Demand Diels-Alder Reaction

被引：8

作者：

Badarau, Eduard ^{[1
,2
]}

Suzenet, Franck ^{[1
]}

Finaru, Adriana-Luminita ^{[2
]}

Guillaumet, Gerald ^{[1
]}

机构：

[1] Univ Orleans, CNRS, UMR 6005, Inst Chim Organ & Analyt,UFR Sci, F-45067 Orleans 2, France

[2] Univ Bacau, Bacau 600115, Romania

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 2009卷 / 21期

关键词：

Heterocycles; Cycloaddition; Polycycles; SEROTONIN; 5-HT7; RECEPTOR; FACILE SYNTHESIS; DERIVATIVES; 1,2,4-TRIAZINES; FURO<2,3-B>PYRIDINES; FUROPYRIDINES; ALDEHYDES; AGONISTS; INHIBITORS; CHROMAN;

D O I：

10.1002/ejoc.200900191

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 3-amino-8-azachromans and 3-amino-7-azabenzofurans derivatives is reported. The synthetic strategy is based on an inverse electron demand Diels-Alder approach, which employs 1,2,4-triazines that are judiciously substituted with amino alkynols. This approach permits the variation of the substituent on the aromatic core and on the amine moiety, as well as of the size of the nonaromatic ring. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

引用

页码：3619 / 3627

页数：9

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