Leukotriene B4 photoaffinity probes:: Design, synthesis and evaluation of new arylazide-1,3-disubstituted cyclohexanes

被引：3

作者：

Durand, D ^{[1
]}

Hullot, P ^{[1
]}

Vidal, JP ^{[1
]}

Girard, JP ^{[1
]}

Banères, JL ^{[1
]}

Parello, J ^{[1
]}

Muller, A ^{[1
]}

Bonne, C ^{[1
]}

Rossi, JC ^{[1
]}

机构：

[1] Fac Pharm Montpellier, UPRESA CNRS 5074, Lab Chim Biomol & Interact Biol, F-34060 Montpellier 2, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)00103-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and the binding affinities of new leukotriene Bq receptor photoaffinity probes, where a 1,3-disubstitued cyclohexane ring replaces the conjugated Delta(6.7) and Delta(8.9) double bonds of the natural eicosanoid, are described. One enantiomeric componnd, 4b alpha, is specifically cross-linked upon photolysis to the recombinant leukotriene Bq receptor from human origin (h-BLTR) solubilized in a micellar medium. This probe appears as a good candidate for identifying the ligand binding site of this receptor. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：811 / 814

页数：4

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