MicroRNA-421 inhibits caspase-10 expression and promotes breast cancer progression

被引：31
|
作者：
Hu, T. B. [1 ,2 ]
Chen, H. S. [2 ]
Cao, M. Q. [2 ]
Guo, F. D. [2 ]
Cheng, X. Y. [1 ]
Han, Z. B. [1 ]
Li, M. Q. [1 ]
机构：
[1] Dalian Med Univ, Dalian, Peoples R China
[2] Dalian Univ, Affiliated Zhongshan Hosp, Dept Bre & Thyroid Surg, Dalian, Peoples R China
来源：
NEOPLASMA | 2018年 / 65卷 / 01期
关键词：
miRNA-421; caspase-10; apoptosis; breast cancer; DOWN-REGULATION; CARCINOMA; APOPTOSIS; MIR-421; PROLIFERATION; PROGNOSIS; SIGNATURE; ATM;
D O I：
10.4149/neo_2018_170306N159
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Breast cancer is one of the most prevalent and fatal diseases around the world. The mechanism of tumorigenesis in breast cancer remains to be clarified. miR-421 plays an oncogenic role in many cancers. Although, the clinical significance of miR-421 in patients with breast cancer is still to he investigated. Caspase-10 is one of the initiator of apoptosis. But the relationship between miR-421 and caspase-10 has not been investigated. In the present study, we found that miR-421 was expressed much higher in breast cancer tissues compared to those in adjacent non-tumor tissues. Furthermore, miR-421 promotes cell proliferation and colony formation in vitro. miR-421 inhibits cell apoptosis probably through restraining caspase-10 expression. Thus, miR-421 might be a potential diagnostic maker and therapeutic target for breast cancer.
引用
收藏
页码：49 / 54
页数：6
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