Transcription factor YY1 mediates epithelial-mesenchymal transition through the TGFβ signaling pathway in bladder cancer

被引：13
|
作者：
Xia, Wuchao [1 ,2 ]
Li, Yuqing [2 ,3 ]
Wu, Zhangsong [2 ]
Wang, Yongqiang [2 ,3 ]
Xing, Nianzeng [4 ]
Yang, Wenzeng [5 ]
Wu, Song [1 ,2 ,3 ]
机构：
[1] Anhui Univ Sci & Technol, Affiliated Shenzhen Luohu Hosp, Shenzhen, Peoples R China
[2] Shenzhen Univ, Affiliated Hosp 3, Urol Inst, Shenzhen, Peoples R China
[3] Guangzhou Med Univ, Affiliated Hosp 1, Dept Urol, Guangdong Key Lab Urol, Shenzhen, Peoples R China
[4] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Clin Res Ctr Canc, Dept Urol,Natl Canc Ctr, Beijing, Peoples R China
[5] Hebei Univ, Affiliated Hosp, Baoding, Hebei, Peoples R China
来源：
MEDICAL ONCOLOGY | 2020年 / 37卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Bladder cancer; EMT; Transcription factor; TGF beta pathway; YY1; EMT; DRIVES;
D O I：
10.1007/s12032-020-01414-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Bladder cancer is one of the most aggressive urothelial tumors. Previous studies have suggested that epithelial-mesenchymal transition (EMT) contributes to bladder cancer progression. However, the regulatory network of EMT in bladder cancer remains elusive. In this study, we found Yin Yang 1 (YY1) is a critical regulator of EMT in bladder cancer. First, we showed that YY1 was upregulated in bladder cancer tissues than that in adjacent normal tissues. Then, we proved that YY1 promoted EMT of bladder cancer cells. Further experiments indicated that YY1 affected the EMT of bladder cancer through transforming growth factor-beta (TGF beta) signaling pathway. Taken together, our study identifies YY1 as a key EMT driver in bladder cancer, suggesting it as a potential therapeutic target.
引用
收藏
页数：10
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