Destabilisation of liposomes by bovine serum albumin; Sepharose 2B-Cl experiment.

被引：6
|
作者：
Michnik, A [1 ]
Sulkowska, A [1 ]
机构：
[1] UNIV SOSNOWIEC,SCH MED,DEPT BIOPHYS CHEM,PL-41200 SOSNOWIEC,POLAND
来源：
CHROMATOGRAPHIA | 1997年 / 45卷 / 1期
关键词：
gel permeation chromatography; bovine serum albumin; stability of liposomes;
D O I：
10.1007/BF02505554
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The stability of liposomes (2:1 egg yolk lecithin:cholesterol, mole ratio; diameter about 100 nm) at increasing bovine serum albumin (BSA) concentration was study. The influence of introducing positive or negative charge to the liposomal bilayers was tested. The results indicated appreciable destructive effects of serum albumin on the liposomal membranes of neutral and negatively charged liposomes. Near-physiological concentration (30 mg mL(-1)) of albumin dissolved more then 50 % of liposomes.
引用
收藏
页码：155 / 157
页数：3
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