Optimization of microbiological parameters for enhanced griseofulvin production using response surface methodology

被引：53

作者：

Dasu, VV ^{[1
]}

Panda, T ^{[1
]}

机构：

[1] Indian Inst Technol, Biotechnol Res Ctr, Biochem Engn Lab, Madras 600036, Tamil Nadu, India

来源：

BIOPROCESS ENGINEERING | 2000年 / 22卷 / 01期

关键词：

D O I：

10.1007/PL00009099

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Central composite design was used to determine the optimal levels of microbiological parameters, viz., slant age, seed age and inoculum level, for enhanced griseofulvin production by Penicillium griseofulvum MTCC 1898 and Penicillium griseofulvum MTCC 2004 in shake flask fermentation. The optimal levels of slant age, seed age and inoculum level for Penicillium griseofulvum MTCC 1898 were found to be 8.8772 days, 4.2093 days, 12% (v/v) (=17.56 kg dry cell mass/m(3)) and for Penicillium griseofulvum MTCC 2004, 8.221 days, 3.4875 days and 9% (v/v) (=8.09 kg dry cell mass/m(3)) respectively. The yield of griseofulvin under optimal conditions was found to be 1.65 times for Penicillium griseofulvum MTCC 1898 and 1.07 times for Penicillium griseofulvum MTCC 2004 higher than that obtained using unoptimized conditions. The fermentation time for maximum production of griseofulvin by Penicillium griseofulvum MTCC 1898 and Penicillium griseofulvum MTCC 2004 decreased by 4 days and 2 days respectively.

引用

页码：45 / 49

页数：5

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