A new compound from an endophytic fungus Alternaria tenuissima

被引：11
|
作者：
Wu, Wen-Bin [1 ]
Yue, Gao-Chao [1 ]
Huang, Qi-Lin [2 ]
Sun, Ling-Ling [1 ]
Zhang, Wen [1 ]
机构：
[1] E China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China
[2] E China Normal Univ, Dept Chem, Shanghai 200241, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2014年 / 16卷 / 07期
基金：
美国国家科学基金会;
关键词：
Alternaria tenuissima; endophytic fungus; altertoxin IV; cytotoxicity; METABOLITES; ANTIFUNGAL;
D O I：
10.1080/10286020.2014.896343
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new secondary metabolite, named altertoxin IV (1), together with altertoxin II (2), was isolated from the fermentation broth of Alternaria tenuissima, an endophytic fungal strain residing in the stem of Tribulus terrestris L. The structure of new compound 1 was established by HR-ESI-MS, multinuclear NMR spectroscopy, and single crystal X-ray diffraction method. In their in vitro bioassay, compound 2 exhibited moderate cytotoxic activity against PC-3 cell lines with an IC50 value of 14.28M.
引用
收藏
页码：777 / 782
页数：6
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