A new compound from an endophytic fungus Alternaria tenuissima

被引：11
|
作者：
Wu, Wen-Bin [1 ]
Yue, Gao-Chao [1 ]
Huang, Qi-Lin [2 ]
Sun, Ling-Ling [1 ]
Zhang, Wen [1 ]
机构：
[1] E China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China
[2] E China Normal Univ, Dept Chem, Shanghai 200241, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2014年 / 16卷 / 07期
基金：
美国国家科学基金会;
关键词：
Alternaria tenuissima; endophytic fungus; altertoxin IV; cytotoxicity; METABOLITES; ANTIFUNGAL;
D O I：
10.1080/10286020.2014.896343
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new secondary metabolite, named altertoxin IV (1), together with altertoxin II (2), was isolated from the fermentation broth of Alternaria tenuissima, an endophytic fungal strain residing in the stem of Tribulus terrestris L. The structure of new compound 1 was established by HR-ESI-MS, multinuclear NMR spectroscopy, and single crystal X-ray diffraction method. In their in vitro bioassay, compound 2 exhibited moderate cytotoxic activity against PC-3 cell lines with an IC50 value of 14.28M.
引用
收藏
页码：777 / 782
页数：6
相关论文
共 50 条
  • [1] New perylenequinone derivatives from the endophytic fungus Alternaria tenuissima SS77
    Chagas, Fernanda O.
    Dias, Luis G.
    Pupo, Monica T.
    TETRAHEDRON LETTERS, 2016, 57 (29) : 3185 - 3189
  • [2] Tricycloalternarene derivatives from endophytic fungus Alternaria tenuissima SY-P-07
    Li, Dong-Mei
    Zhang, Yu-Hong
    Ji, Hai-Xia
    Wu, Xin
    Pei, Yue-Hu
    Bai, Jiao
    NATURAL PRODUCT RESEARCH, 2013, 27 (20) : 1877 - 1881
  • [3] A new isocoumarin from metabolites of the endophytic fungus Alternaria tenuissima(Nees & T.Nees:Fr.) Wiltshire
    Zhen Feng Fang
    Chinese Chemical Letters, 2012, 23 (03) : 317 - 320
  • [4] A new isocoumarin from metabolites of the endophytic fungus Alternaria tenuissima (Nees & T. Nees: Fr.) Wiltshire
    Fang, Zhen Feng
    Yu, Shi Shan
    Zhou, Wan Qi
    Chen, Xiao Guang
    Ma, Shuang Gang
    Li, Yong
    Qu, Jing
    CHINESE CHEMICAL LETTERS, 2012, 23 (03) : 317 - 320
  • [5] New Secondary Metabolites from the Endophytic Fungus Alternaria phragmospora
    Metwaly, A. M.
    Kadry, H. A.
    El-Hela, A. A.
    Mohammad, A. E., I
    Cutler, S. J.
    Ross, S. A.
    PLANTA MEDICA, 2013, 79 (10) : 852 - 853
  • [6] Two new compounds from an endophytic fungus Alternaria solani
    Ai, Hong-Lian
    Zhang, Li-Mei
    Chen, Yan-Ping
    Zi, Shu-Hui
    Xiang, Hong
    Zhao, Da-Ke
    Shen, Yong
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2012, 14 (12) : 1144 - 1148
  • [7] Pyrone derivatives from the endophytic fungus Alternaria tenuissima SP-07 of Chinese herbal medicine Salvia przewalskii
    Wang, Xiao-Zheng
    Luo, Xiao-Hong
    Xiao, Jie
    Zhai, Ming-Ming
    Yuan, Yun
    Zhu, Ying
    Crews, Phillip
    Yuan, Cheng-Shan
    Wu, Quan-Xiang
    FITOTERAPIA, 2014, 99 : 184 - 190
  • [8] A new compound from an endophytic fungus Bambusicola massarinia
    Zhou, Kun
    Zheng, Xin-Ge
    Sun, Zhong-Yi
    Gao, Yu-Jing
    Wang, Zhong
    Gao, Wen-Bin
    Luo, Du-Qiang
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2016, 18 (12) : 1200 - 1204
  • [9] New antimalarial benzopyran derivatives from the endophytic fungus Alternaria phragmospora
    Metwaly, A.
    Kadry, H.
    El-Hela, A.
    Elsalam, A.
    Ross, S.
    PLANTA MEDICA, 2014, 80 (10) : 770 - 771
  • [10] Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192
    Hong Sun
    Shushan Gao
    Xiaoming Li
    Chunshun Li
    Bingui Wang
    Chinese Journal of Oceanology and Limnology, 2013, 31 : 464 - 470
12345