3-Aroylindoles via Copper-Catalyzed Cyclization of N-(2-Iodoaryl)enaminones

被引：23
|
作者：
Bernini, Roberta [2 ,3 ]
Cacchi, Sandro [1 ]
Fabrizi, Giancarlo [1 ]
Filisti, Eleonora [1 ]
Sferrazza, Alessio [2 ,3 ]
机构：
[1] Univ Roma La Sapienza, Dipartimento Chim & Tecnol Farmaco, I-00185 Rome, Italy
[2] Univ Tuscia, Dipartimento ABAC, I-01100 Viterbo, Italy
[3] Consorzio Univ La Chim Ambiente, I-01100 Viterbo, Italy
来源：
SYNLETT | 2009年 / 09期
关键词：
indoles; enaminones; cyclization; copper; catalysis; ACTIVATING-FACTOR ANTAGONISTS; 2,3-DISUBSTITUTED INDOLES; BOND FORMATION; PALLADIUM; ARYLATION; ACYLATION; 3-ACYLINDOLES; ENAMINONES; ELLIPTICINE; PYRROLES;
D O I：
10.1055/s-0029-1216742
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
3-Aroylindoles have been prepared via copper-catalyzed cyclization of N-(2-iodoaryl)enaminones, readily available from 2-iodoanilines and alpha,beta-ynones. The reaction tolerates a variety of useful functionalities including ether, keto, cyano, bromo, and chloro substituents. This indole synthesis can also be carried out from 2-iodoanilines and alpha,beta-ynones through a sequential process that omits the isolation of enaminone intermediates.
引用
收藏
页码：1480 / 1484
页数：5
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