Biosynthesis of streptolydigin: Origin of the oxygen atoms

被引:8
|
作者
Chen, Hao [1 ]
Olesen, Solveig G. [1 ]
Harrison, Paul H. M. [1 ]
机构
[1] McMaster Univ, Dept Chem, Hamilton, ON L8S 4M1, Canada
关键词
D O I
10.1021/ol0621304
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] Biosynthetic incorporations of [C-13, O-18]-labeled precursors into streptolydigin reveal the origin of the oxygen atoms, limiting the possible pathways for acyltetramic acid ring assembly and for formation of the bicyclic ketal.
引用
收藏
页码:5329 / 5332
页数:4
相关论文
共 50 条
  • [21] BIOSYNTHESIS OF THE C15 MACROLIDE ANTIBIOTICS .1. BIOCHEMICAL ORIGIN OF THE 4 OXYGEN-ATOMS IN BREFELDIN A
    MABUNI, CT
    GARLASCHELLI, L
    ELLISON, RA
    HUTCHINSON, CR
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1979, 101 (03) : 707 - 714
  • [22] ORIGIN OF OXYGEN-ATOMS IN CANTHARIDIN BIOSYNTHESIZED BY BEETLES
    MCCORMICK, JP
    CARREL, JE
    DOOM, JP
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (25) : 8071 - 8074
  • [23] BIOSYNTHETIC ORIGIN OF THE OXYGEN-ATOMS OF AQUAYAMYCIN - ASPECTS FOR THE BIOSYNTHESIS OF THE URDAMYCIN FAMILY AND FOR AQUAYAMYCIN-CONTAINING ANGUCYCLINE ANTIBIOTICS IN GENERAL
    UDVARNOKI, G
    HENKEL, T
    MACHINEK, R
    ROHR, J
    JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (04): : 1274 - 1276
  • [24] THE BIOSYNTHESIS OF ANTIBIOTIC F-244 IN FUSARIUM SP ATCC-20788 - ORIGIN OF THE CARBON, HYDROGEN, AND OXYGEN-ATOMS
    SAEPUDIN, E
    HARRISON, P
    CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1995, 73 (01): : 1 - 5
  • [25] Deciphering Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin and Generation of Glycosylated Derivatives
    Olano, Carlos
    Gomez, Cristina
    Perez, Maria
    Palomino, Martina
    Pineda-Lucena, Antonio
    Carbajo, Rodrigo J.
    Brana, Alfredo F.
    Mendez, Carmen
    Salas, Jose A.
    CHEMISTRY & BIOLOGY, 2009, 16 (10): : 1031 - 1044
  • [26] BIOSYNTHETIC ORIGIN OF THE CARBON SKELETON AND OXYGEN-ATOMS OF THE AVERMECTINS
    CANE, DE
    LIANG, TC
    KAPLAN, L
    NALLIN, MK
    SCHULMAN, MD
    HENSENS, OD
    DOUGLAS, AW
    ALBERSSCHONBERG, G
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (12) : 4110 - 4112
  • [27] BIOSYNTHETIC ORIGIN OF CARBOXYL OXYGEN ATOMS OF CAROTENOID PIGMENT TORULARHODIN
    SIMPSON, KL
    NAKAYAMA, TO
    CHICHESTER, CO
    BIOCHEMICAL JOURNAL, 1964, 92 (03) : 508 - &
  • [28] BIOSYNTHETIC ORIGIN OF THE OXYGEN-ATOMS OF TETRACENOMYCIN-C
    UDVARNOKI, G
    WAGNER, C
    MACHINEK, R
    ROHR, J
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1995, 34 (05): : 565 - 567
  • [29] Biosynthesis of RNA polymerase inhibitor streptolydigin, pathway regulation and generation of novel derivatives
    Olano, C.
    Gomez, C.
    Horna, D. H.
    Brana, A. F.
    Mendez, C.
    Salas, J. A.
    FEBS JOURNAL, 2012, 279 : 331 - 332
  • [30] Three pathway-specific regulators control streptolydigin biosynthesis in Streptomyces lydicus
    Gomez, Cristina
    Olano, Carlos
    Mendez, Carmen
    Salas, Jose A.
    MICROBIOLOGY-SGM, 2012, 158 : 2504 - 2514