Cell kinetics of pleomorphic adenomas of the parotid gland

被引：9
|
作者：
Matturri, L [1 ]
Lavezzi, AM [1 ]
Biondo, B [1 ]
Mantovani, M [1 ]
机构：
[1] UNIV MILAN,INST OTORHINOLARYNGOL,I-20122 MILAN,ITALY
来源：
ORAL ONCOLOGY-EUROPEAN JOURNAL OF CANCER PART B | 1996年 / 32B卷 / 03期
关键词：
cell kinetics; DNA content; PCNA index; pleomorphic adenoma; parotid gland;
D O I：
10.1016/0964-1955(95)00090-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of the present study is to characterise the cell kinetics of pleomorphic adenoma of the parotid gland by assessing DNA content and proliferating cell nuclear antigen (PCNA) positivity. In 22 parotid adenomas, DNA content was measured by densitometry in histological serial sections stained with Feulgen's method and PCNA positivity was determined by immunohistochemistry with the monoclonal antibody PC10. To assess the proliferative activity, DNA index and PCNA index were evaluated. It was possible to distinguish two types of adenoma. In Group I there was a prevalence of diploid cells with a low PCNA index. Group II is represented by adenomas with a large percentage of triploid cells and a PCNA index significantly higher than that of Group I. Our findings suggest that the possibility of recurrence or malignant transformation depends on intrinsic biological properties of each adenoma. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：154 / 157
页数：4
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