Kinetics of base catalyzed racemization of ibuprofen enantiomers

被引：54
|
作者：
Xie, YC [1 ]
Liu, HZ [1 ]
Chen, JY [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem Met, Beijing 100080, Peoples R China
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2000年 / 196卷 / 01期
关键词：
ibuprofen enantiomer; resolution; racemization kinetics; base catalysis;
D O I：
10.1016/S0378-5173(99)00438-X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The kinetics of base catalyzed racemization of ibuprofen enantiomers has been studied in DMSO-water mixed medium. The dynamic equilibrium rate of keto-enol tautomerism leading to racemization of ibuprofen enantiomers, is proportional to the concentrations of base catalyst and substrate. A kinetic model capable of predicting the time course of racemization. under different base and substrate concentrations, is, established and experimentally verified. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：21 / 26
页数：6
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