A Therapeutic System of 177Lu-labeled Gold Nanoparticles-RGD Internalized in Breast Cancer Cells

被引：0
|
作者：
Luna-Gutierrez, Myrna [1 ,2 ]
Ferro-Flores, Guillermina [1 ]
Ocampo-Garcia, Blanca E. [1 ]
Santos-Cuevas, Clara L. [1 ]
Jimenez-Mancilla, Nallely [1 ,2 ]
De Leon-Rodriguez, L. M. [3 ]
Azorin-Vega, Erika [1 ]
Isaac-Olive, Keila [2 ]
机构：
[1] Inst Nacl Invest Nucl, Dept Mat Radiactivos, Toluca, Estado De Mexic, Mexico
[2] Univ Autonoma Estado Mexico, Fac Med, Toluca, Estado De Mexic, Mexico
[3] Univ Guanajuato, Dept Quim, Guanajuato, Mexico
来源：
JOURNAL OF THE MEXICAN CHEMICAL SOCIETY | 2013年 / 57卷 / 03期
关键词：
gold nanoparticles; radiolabeled nanoparticles; radio-gold nanoparticles; radiolabeled peptides; nanoparticle-peptide; RGD peptide; lutetium-177; IN-VITRO; PEPTIDES; LIGANDS;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The aim of this research was to evaluate the in vitro potential of Lu-177-labeled gold nanoparticles conjugated to cyclo-[RGDfK(C)] peptides (Lu-177-AuNP-c[RGDfK(C)]) as a plasmonic photothermal therapy and targeted radiotherapy system in MCF7 breast cancer cells. Peptides were conjugated to AuNPs (20 nm) by spontaneous reaction with the thiol group of cysteine (C). After laser irradiation, the presence of c[RGDfK(C)]-AuNP in cells caused a significant increase in the temperature of the medium (50.5 C, compared to 40.3 C without AuNPs) resulting in a significant decrease in MCF7 cell viability down to 9 %. After treatment with Lu-177-AuNP-c[RGDfK(C)], the MCF7 cell proliferation was significantly inhibited.
引用
收藏
页码：212 / 219
页数：8
相关论文
共 50 条
  • [31] 177Lu-labeled PSMA targeting therapeutic with optimized linker for treatment of disseminated prostate cancer; evaluation of biodistribution and dosimetry
    Abouzayed, Ayman
    Seitova, Kamila
    Lundmark, Fanny
    Bodenko, Vitalina
    Oroujeni, Maryam
    Tolmachev, Vladimir
    Rosenstrom, Ulrika
    Orlova, Anna
    FRONTIERS IN ONCOLOGY, 2023, 13
  • [32] 177Lu-Labeled Eu-Doped Mesoporous SiO2 Nanoparticles as a Theranostic Radiopharmaceutical for Colorectal Cancer
    Viana, Rodrigo da Silva
    de Mescana Costa, Luciana Amaral
    Harmon, Ashlyn C.
    Gomes Filho, Manoel Adriao
    Falcao, Eduardo H. L.
    Vicente, Maria G. H.
    Junior, Severino A.
    Mathis, J. Michael
    ACS APPLIED NANO MATERIALS, 2020, 3 (09): : 8691 - 8701
  • [33] Targeting Breast Cancer Using 177Lu-Labeled Trastuzumab and Trastuzumab Fragment First-in-Human Clinical Experience
    Rathore, Yogesh
    Lakhanpal, Tamanna
    Chakraborty, Sudipta
    Chakravarty, Rubel
    Mittal, B. R.
    Irrinki, R. N. Santhosh
    Laroiya, Ishita
    Kaur, Komalpreet
    Shukla, Jaya
    CLINICAL NUCLEAR MEDICINE, 2024, 49 (06) : e258 - e265
  • [34] Prospects of medium specific activity 177Lu in targeted therapy of prostate cancer using 177Lu-labeled PSMA inhibitor
    Chakraborty, Sudipta
    Chakravarty, Rubel
    Shetty, Priyalata
    Vimalnath, K. V.
    Sen, Ishita B.
    Dash, Ashutosh
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2016, 59 (09): : 364 - 371
  • [35] Preparation and characterization of 90Y- and 177Lu-labeled cetuximab for therapeutic applications in vitro and in vivo
    Zenker, Martin
    Bergmann, Ralf
    Walther, Martin
    Heldt, Jan-Martin
    Pietzsch, Jens
    Pietzsch, Hans-Juergen
    Steinbach, Joerg
    NUCLEAR MEDICINE AND BIOLOGY, 2010, 37 (06) : 723 - 723
  • [36] Comparison of the Therapeutic Response to Treatment with a 177Lu-Labeled Somatostatin Receptor Agonist and Antagonist in Preclinical Models
    Dalm, Simone U.
    Nonnekens, Julie
    Doeswijk, Gabriela N.
    de Blois, Erik
    van Gent, Dik C.
    Konijnenberg, Mark W.
    de Jong, Marion
    JOURNAL OF NUCLEAR MEDICINE, 2016, 57 (02) : 260 - 265
  • [37] [177Lu]Lu-labeled gold nanoparticles as tumor hypoxia targeting platforms
    Mittal, Sweety
    Mallia, Madhava
    Sharma, Rohit
    Sarma, Haladhar D.
    NUCLEAR MEDICINE AND BIOLOGY, 2021, 96-97 : S85 - S86
  • [38] Single vial kit formulation of DOTATATE for preparation of 177Lu-labeled therapeutic radiopharmaceutical at hospital radiopharmacy
    Mukherjee, Archana
    Lohar, Sharad
    Dash, Ashutosh
    Sarma, Haladhar Dev
    Samuel, Grace
    Korde, Aruna
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2015, 58 (04): : 166 - 172
  • [39] Potential therapeutic radiotracers: preparation, biodistribution and metabolic characteristics of 177Lu-labeled cyclic RGDfK dimer
    Jiyun Shi
    Zhaofei Liu
    Bing Jia
    Zilin Yu
    Huiyun Zhao
    Fan Wang
    Amino Acids, 2010, 39 : 111 - 120
  • [40] Potential therapeutic radiotracers: preparation, biodistribution and metabolic characteristics of 177Lu-labeled cyclic RGDfK dimer
    Shi, Jiyun
    Liu, Zhaofei
    Jia, Bing
    Yu, Zilin
    Zhao, Huiyun
    Wang, Fan
    AMINO ACIDS, 2010, 39 (01) : 111 - 120
12345