Palladium-Catalyzed Imidoylation-Triggered [2+2+1] Cyclization of Internal Alkyne with Isocyanides

被引：15
|
作者：
Huang, Keke [1 ,2 ]
Liu, Jin-Biao [1 ]
Chen, Zhi-Feng [2 ]
Wang, Yu-Chao [2 ]
Yadav, Sarita [2 ]
Qiu, Guanyinsheng [2 ]
机构：
[1] Jiangxi Univ Sci & Technol, Sch Met & Chem Engn, Ganzhou 341000, Peoples R China
[2] Jiaxing Univ, Coll Biol Chem Sci & Engn, Jiaxing 314001, Zhejiang, Peoples R China
来源：
ORGANIC LETTERS | 2020年 / 22卷 / 15期
基金：
中国国家自然科学基金;
关键词：
ALPHA; BETA-UNSATURATED CARBONYL-COMPOUNDS; CASCADE REACTIONS; MIGRATORY INSERTION; 4+1 CYCLOADDITION; ISONITRILES; MULTICOMPONENT; ACTIVATION; KETENIMINE; PROGRESS; CONSTRUCTION;
D O I：
10.1021/acs.orglett.0c02019
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this work, a palladium-catalyzed [2 + 2 + 1] cyclization of internal alkynes with double isocyanides is described. This facile procedure is efficient for synthesizing various pyrrolo-[3,2-c]quinolin-2-amines. The reaction worked well with a broad reaction scope. In the process, it is believed that sequential double isocyanide insertion, 6-exo-dig cyclization of alkyne, and addition of an imino group are involved.
引用
收藏
页码：5931 / 5935
页数：5
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