Aerobic Plus Resistance Exercise in Obese Older Adults Improves Muscle Protein Synthesis and Preserves Myocellular Quality Despite Weight Loss

被引：90

作者：

Colleluori, Georgia ^{[1
,2
,11
]}

Aguirre, Lina ^{[3
,4
]}

Phadnis, Uma ^{[1
,2
]}

Fowler, Kenneth ^{[3
,4
]}

Armamento-Villarea, Reina ^{[1
,2
]}

Sun, Zheng ^{[1
]}

Brunetti, Lorenzo ^{[5
]}

Park, Jun Hyoung ^{[6
]}

Kaipparettu, Benny Abraham ^{[6
]}

Putluri, Nagireddy ^{[6
,7
]}

Auetumrongsawat, Vimlin ^{[1
,2
]}

Yarasheski, Kevin ^{[8
]}

Qualls, Clifford ^{[9
,10
]}

Villarea, Dennis T. ^{[1
,2
]}

机构：

[1] Baylor Coll Med, Div Endocrinol Diabet & Metab, Houston, TX 77030 USA

[2] Michael E DeBakey VA Med Ctr, CTRID, Houston, TX 77030 USA

[3] Univ New Mexico, Sch Med, New Mexico VA Hlth Care Syst, Med Care Line, Albuquerque, NM 87108 USA

[4] Univ New Mexico, Sch Med, Dept Internal Med, Albuquerque, NM 87108 USA

[5] Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

[6] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[7] Baylor Coll Med, Adv Technol Core, Houston, TX 77030 USA

[8] Washington Univ, Sch Med, Dept Internal Med, Div Metab Endocrinol & Diabet, St Louis, MO 63110 USA

[9] Univ New Mexico, Dept Math & Stat, Sch Med, Albuquerque, NM 87108 USA

[10] Univ New Mexico, Sch Med, Albuquerque, NM 87108 USA

[11] Univ Politecn Marche, Dept Clin & Expt Med, Via Tronto 10A, I-60020 Ancona, Italy

来源：

CELL METABOLISM | 2019年 / 30卷 / 02期

关键词：

FRACTIONAL SYNTHESIS RATE; TERMINAL AGRIN FRAGMENT; SKELETAL-MUSCLE; CALORIC RESTRICTION; INSULIN SENSITIVITY; ANABOLIC RESPONSE; ELDERLY-MEN; FED STATE; METABOLISM; STRENGTH;

D O I：

10.1016/j.cmet.2019.06.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Anabolic resistance and impaired myocellular quality contribute to age-related sarcopenia, which exacerbates with obesity. Diet-induced muscle mass loss is attenuated by resistance or aerobic plus resistance exercise compared to aerobic exercise in obese elderly. We assessed chronic effects of weight loss plus different exercise modalities on muscle protein synthesis response to feeding and myocellular quality. Obese older adults were randomized to a weight-management program plus aerobic, resistance, or combined aerobic and resistance exercise or to control. Participants underwent vastus lateralis biopsies at baseline and 6 months. Muscle protein synthesis rate increased more in resistance and combined than in control. Autophagy mediators' expression decreased more in combined than in aerobic, which experienced a higher increase in inflammation and mitochondrial regulators' expression. In obese elderly, combined aerobic and resistance exercise is superior to either mode independently for improving muscle protein synthesis and myocellular quality, thereby maintaining muscle mass during weight-loss therapy.

引用

页码：261 / +

页数：19

共 50 条

[41] Effects Of Diet-induced Weight Loss With Or Without Moderate Aerobic Exercise On Skeletal Muscle Mass In Overweight Older Adults
Chomentowski, Peter J., III
Dube, John
Amati, Francesca
Goodpaster, Bret H.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2008, 40 (05): : S75 - S75
[42] Resistance Training During Weight Loss in Overweight and Obese Older Adults: What Are the Benefits?
Delmonico, Matthew J.
Lofgren, Ingrid E.
AMERICAN JOURNAL OF LIFESTYLE MEDICINE, 2010, 4 (04) : 309 - 313
[43] Intensive weight loss program improves physical function in older obese adults with knee osteoarthritis
Miller, Gary D.
Nicklas, Barbara J.
Davis, Cralen
Loeser, Richard F.
Lenchik, Leon
Messier, Stephen P.
OBESITY, 2006, 14 (07) : 1219 - 1230
[44] Aerobic Exercise Enhances The Muscle Protein Anabolic Effect Of A Mixed Meal In Older Adults
Timmerman, Kyle L.
Dhanani, Shaheen
Glynn, Erin L.
Fry, Christopher S.
Drummond, Micah J.
Rasmussen, Blake B.
Volpi, Elena
FASEB JOURNAL, 2010, 24
[45] Aerobic exercise improves self-reported sleep and quality of life in older adults with insomnia
Reid, Kathryn J.
Baron, Kelly Glazer
Lu, Brandon
Naylor, Erik
Wolfe, Lisa
Zee, Phyllis C.
SLEEP MEDICINE, 2010, 11 (09) : 934 - 940
[46] RAGE EXPRESSION IN HUMAN SKELETAL MUSCLE IS NORMALIZED FOLLOWING AEROBIC EXERCISE TRAINING IN OLDER OBESE ADULTS
Mahmoud, A. M.
Somal, V.
Haus, J. M.
Solomon, T. P.
Kasumov, T.
Fealy, C. E.
Malin, S. K.
Kirwan, J. P.
JOURNAL OF INVESTIGATIVE MEDICINE, 2013, 61 (04) : 788 - 788
[47] Does Weight Loss And Exercise Training Alter Hormone Levels In Older Obese And Overweight Adults?
Steiner, Michelle J.
Miller, Gary D.
Davis, Cralen C.
Nicklas, Barbara J.
Messier, Stephen P.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2005, 37 : S353 - S353
[48] Exercise And Dietary Weight Loss In Overweight And Obese Older Adults With Knee OA: Effects On Gait
Messier, Stephen P.
Brown, Ryan
Gutekunst, David J.
Davis, Cralen
Jolla, Jovita
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2005, 37 : S54 - S54
[49] Effect of Exercise Modality During Weight Loss on Body Mass and Composition in Older Obese Adults
Beavers, K.
Rejeski, W.
Marsh, A.
Ambrosius, W.
Walkup, M.
GERONTOLOGIST, 2016, 56
[50] Muscle Protein Synthesis Response to Exercise Training in Obese, Older Men and Women
Smith, Gordon I.
Villareal, Dennis T.
Sinacore, David R.
Shah, Krupa
Mittendorfer, Bettina
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2012, 44 (07): : 1259 - 1266

← 1 2 3 4 5 →