Phosphine-mediated one-pot thiol-ene "click'' approach to polymer-protein conjugates

被引：101

作者：

Jones, Mathew W. ^{[1
]}

Mantovani, Giuseppe ^{[2
]}

Ryan, Sinead M. ^{[3
,4
]}

Wang, Xuexuan ^{[3
,4
]}

Brayden, David J. ^{[3
,4
]}

Haddleton, David M. ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England

[3] Univ Coll Dublin, Sch Agr Food Sci & Vet Med, Dublin 4, Ireland

[4] Univ Coll Dublin, Conway Inst, Dublin 4, Ireland

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 35期

基金：

爱尔兰科学基金会;

关键词：

SITE-SPECIFIC PEGYLATION; NATIVE DISULFIDE BONDS; THERAPEUTIC PROTEINS; ORTHOGONAL SYNTHESIS; CHEMISTRY; REDUCTION; EFFICIENT; DELIVERY; ROBUST; BRIDGE;

D O I：

10.1039/b906865a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We employ water-soluble organic phosphines as key reagents in a one-pot synthetic protocol where a (poly)peptide disulfide bridge is first reduced followed by subsequent reaction of the two thiols in situ with poly(monomethoxy ethylene glycol)-(meth) acrylates (p(mPEG)(M)A); we use salmon calcitonin (sCT) as a disulfide bridge-containing peptide, which contains a disulfide bridge-Cys1-Cys7-that can be reduced to give two sulfhydryl units available for thiol functionalisation; bioactivity is retained.

引用

页码：5272 / 5274

页数：3

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