Varying the Constant: Mechanisms of Fc-Mediated Immunity to Influenza Virus

被引：0

作者：

Kastenschmidt, Jenna M. ^{[1
,2
]}

Wagar, Lisa E. ^{[1
,2
]}

机构：

[1] Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92717 USA

[2] Univ Calif Irvine, Inst Immunol, Irvine, CA 92717 USA

来源：

CELL HOST & MICROBE | 2020年 / 28卷 / 06期

关键词：

ANTIBODIES;

D O I：

10.1016/j.chom.2020.11.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antibodies are typically thought to mediate antiviral immunity by blocking host-cell infection. However, immunoglobulin G (IgG) can also stimulate antiviral responses through its constant region. A recent study in Nature (Bournazos et al., 2020) shows that modifying Fc binding affinities to better target Fc.RIIa enhances the influenza CD8 T cell response.

引用

页码：769 / 770

页数：2

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