Extracellular RNA in kidney disease: moving slowly but surely from bench to bedside

被引：2
|
作者：
Hunter, Robert W.
Dhaun, Neeraj [1 ]
机构：
[1] Royal Infirm Edinburgh NHS Trust, Dept Renal Med, Edinburgh EH16 4SA, Midlothian, Scotland
来源：
CLINICAL SCIENCE | 2020年 / 134卷 / 21期
基金：
英国惠康基金;
关键词：
VESICLES; HYPOXIA;
D O I：
10.1042/CS20201092
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We have known for just over a decade that functional RNA is shuttled between cells (Nat. Cell Biol. (2007) 9, 654-659). In that short time, there have been countless reports of extracellular RNA (exRNA) and extracellular vesicles (EVs) participating in diverse biological processes in development (Dev. Cell (2017) 40, 95-103), homoeostasis (Nature (2017) 542, 450-455) and disease (Nature (2017) 546, 498-503). Unsurprisingly - as these disciplines are still in their infancies - most of this work is still in the 'discovery biology' phase. However, exRNA and EVs show promise as disease biomarkers and could be harnessed in novel therapies.
引用
收藏
页码：2893 / 2895
页数：3
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