Background: Low back pain is an incredibly Complaint experienced by different individuals ages. In 2015, the worldwide point commonness of movement constraining low back torment was 7.3%, suggesting that 540 million individuals were influenced at any one time. Low back pain is a symptom, not a disease, and can result from a few diverse known or obscure irregularities or sicknesses. It is characterized by the area of agony, regularly between the lower rib edges and the butt cheek creases. Aim: To determine the prevalence of low-back pain and explore factors associated with MSP among medical students at Umm Al-Qura4 University Saudi Arabia. Method: A cross-sectional survey was performed among medical students in Umm Al-Qura University during the period from 12 June 2020 to 12 October, 2020. The survey included 366 students whose ages ranged from 18 to 25 years old. The Statistical Package for Social Sciences (SPSS) version 24.0 was used in the analysis. Results: A total of 366 students were involved in this study, 249 (68%) of them were females 68%. As for BMI, exact of 236 (64.5%) were at normal weight while 45 (12.3%) were obese. Exact of 277 (75.7%) students complained of LBP during the last period related to trauma. As for aggravating factors, the long sitting session was the most reported factor (75.2%) followed by wrong sleep position (58.5%), sedentary lifestyle (45%), inappropriate lifting (28.7%), and stress (27.9%), while long-standing (4.7%), and menses (2.3%) were the least reported factors. The most-reported red flags of back pain were neck pain (39.1%) followed by weakness (16.7%), leg weakness (11.6%), numbness (10.1%), and loss of knee reflex (4.7%). Conclusion: LBP was more among females and mainly related to inappropriate sleep, setting, or even studying positions. Neck pain was the most reported with a low mood. Lack of exercise with long study hours was remarkably reported. Also, irrespective of the high prevalence of reported LBP, but there was no considerable effect on student's scholastic performance.