Low-Dose Dexamethasone Does Not Abrogate the Immunomodulatory Effects of Lenalidomide and Both Reactivate the Impaired Immune System of High-Risk Smoldering Multiple Myeloma Patients

被引:0
|
作者
Paiva, Bruno [1 ]
Mateos, Maria-Victoria [2 ]
Ignacio Sanchez-Abarca, Luis [3 ]
Belen Vidriales, Maria [4 ]
Lopez-Corral, Lucia [5 ]
Corchete, Luis A. [5 ]
Hernandez, Miguel T. [6 ]
Bargay, Joan [7 ]
De Arriba, Felipe [8 ]
De la Rubia, Javier [9 ]
Isabel Teruel, Ana [10 ]
Giraldo, Pilar [11 ]
Rosinol, Laura [12 ]
Prosper, Felipe [13 ]
Oriol, Albert [14 ]
Mariano Hernandez, Jose [15 ]
Esteves, Graca [16 ]
da Costa, Fernando Leal [17 ]
Jose Lahuerta, Juan [18 ]
Blade, Joan [12 ]
Perez-Simon, Jose A. [19 ]
San Miguel, Jesus [20 ]
机构
[1] Univ Navarra Clin, Dept Hematol & Immunol, Pamplona, Spain
[2] Univ Hosp Salamanca IBSAL, Dept Hematol, Salamanca, Spain
[3] IBSAL Hosp Univ Salamanca, Serv Hematol, Salamanca, Spain
[4] Hosp Univ Salamanca, Dept Hematol, Salamanca, Spain
[5] Hosp Univ Salamanca, Salamanca, Spain
[6] Univ Hosp, Santa Cruz, CA USA
[7] Hosp Son Llatzer, Palma de Mallorca, Spain
[8] Hosp Univ Morales Meseguer, Ctr Reg Hemodonac, Hematol & Clin Oncol Unit, Murcia, Spain
[9] HUP La Fe, Valencia, Spain
[10] Hosp Clin Valencia, Valencia, Spain
[11] Minist Publ Hlth Russia, Hematol Res Ctr, Moscow, Russia
[12] Hosp Clin Barcelona, Barcelona, Spain
[13] Univ Navarra Clin, Pamplona, Spain
[14] Hosp Badalona Germans Trias & Pujol, lnst Catala Oncol, Barcelona, Spain
[15] Hosp Gen Segovia, Segovia, Spain
[16] Hosp Santa Maria, Lisbon, Portugal
[17] nst Portugues Oncol, Lisbon, Portugal
[18] Hosp 12 Octubre, E-28041 Madrid, Spain
[19] Hosp Univ Virgen Rocio, Dept Hematol, Seville, Spain
[20] Univ Navarra, Univ Navarra Clin, Ctr Invest Med Aplicada, E-31080 Pamplona, Spain
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:3
相关论文
共 50 条
  • [31] Circulating immune cell phenotype can predict the outcome of lenalidomide plus low-dose dexamethasone treatment in patients with refractory/relapsed multiple myeloma
    Sung-Eun Lee
    Ji-Young Lim
    Da-Bin Ryu
    Tae Woo Kim
    Jae-Ho Yoon
    Byung-Sik Cho
    Ki-Seong Eom
    Yoo-Jin Kim
    Hee-Je Kim
    Seok Lee
    Seok-Goo Cho
    Dong-Wook Kim
    Jong-Wook Lee
    Woo-Sung Min
    Myungshin Kim
    Chang-Ki Min
    Cancer Immunology, Immunotherapy, 2016, 65 : 983 - 994
  • [32] Circulating immune cell phenotype can predict the outcome of lenalidomide plus low-dose dexamethasone treatment in patients with refractory/relapsed multiple myeloma
    Lee, Sung-Eun
    Lim, Ji-Young
    Ryu, Da-Bin
    Kim, Tae Woo
    Yoon, Jae-Ho
    Cho, Byung-Sik
    Eom, Ki-Seong
    Kim, Yoo-Jin
    Kim, Hee-Je
    Lee, Seok
    Cho, Seok-Goo
    Kim, Dong-Wook
    Lee, Jong-Wook
    Min, Woo-Sung
    Kim, Myungshin
    Min, Chang-Ki
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2016, 65 (08) : 983 - 994
  • [33] Clinical and Correlative Pilot Study Of Carfilzomib, Lenalidomide, and Dexamethasone Followed By Lenalidomide Extended Dosing (CRd - R) In High Risk Smoldering Multiple Myeloma Patients
    Landgren, Ola
    Mailankody, Sham
    Kwok, Mary
    Manasanch, Elisabet E.
    Bhutani, Manisha
    Tageja, Nishant
    Kazandjian, Dickran
    Zingone, Adriana
    Costello, Rene
    Burton, Debra
    Zhang, Yong
    Wu, Peter
    Carter, George
    Mulquin, Marcia
    Zuchlinski, Diamond
    Maric, Irina
    Calvo, Katherine R.
    Braylan, Raul C.
    Yuan, Constance
    Stetler-Stevenson, Maryalice
    Arthur, Diane C.
    Lindenberg, Liza
    Kurdziel, Karen
    Choyke, Peter
    Steinberg, Seth M.
    Roschewski, Mark
    Korde, Neha
    BLOOD, 2013, 122 (21)
  • [34] Phase III trial of thalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone in newly diagnosed multiple myeloma
    不详
    CLINICAL LYMPHOMA & MYELOMA, 2007, 7 (07): : 452 - 453
  • [35] Multiparameter Flow Cytometry Analysis of Peripheral Blood T, NK and Dendritic Cells From High-Risk Smoldering Multiple Myeloma Patients Treated with Lenalidomide and Dexamethasone
    Paiva, Bruno
    Lopez-Corral, Lucia
    Vidriales, Maria-Belen
    Sanchez Abarca, Luis Ignacio
    Hernandez, Miguel T.
    Bargay, Joan
    De La Rubia, Javier
    Giraldo, Pilar
    Teruel, Ana-Isabel
    Rosinol, Laura
    Oriol, Albert
    Hernandez, Jose
    de Arriba, Felipe
    Esteves, Graca
    Perez Simon, Jose Antonio
    Mateos, Maria-Victoria
    San Miguel, Jesus F.
    BLOOD, 2010, 116 (21) : 794 - 795
  • [36] Phase II study of pegylated liposomal doxorubicin, low-dose dexamethasone, and lenalidomide in patients with newly diagnosed multiple myeloma
    Baz, Rachid C.
    Shain, Kenneth H.
    Hussein, Mohamad A.
    Lee, Ji-Hyun
    Sullivan, Daniel M.
    Oliver, Elizabeth Finley
    Nardelli, Lisa A.
    Nodzon, Lisa A.
    Zhao, Xiuhua
    Ochoa-Bayona, Jose Leonel
    Nishihori, Taiga
    Dalton, William S.
    Alsina, Melissa
    AMERICAN JOURNAL OF HEMATOLOGY, 2014, 89 (01) : 62 - 67
  • [37] A randomized phase II study of elotuzumab with lenalidomide and low-dose dexamethasone in patients with relapsed/refractory multiple myeloma.
    Moreau, Philippe
    Richardson, Paul Gerard Guy
    Jakubowiak, Andrzej J.
    Jagannath, Sundar
    Raab, Marc
    Facon, Thierry
    Vij, Ravi
    Reece, Donna Ellen
    White, Darrell
    Benboubker, Lotfi
    Zonder, Jeffrey A.
    Rossi, Jean-Francois
    Tsao, Claire
    Parli, Teresa
    Kroog, Glenn Scott
    Singhal, Anil
    Lonial, Sagar
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)
  • [38] Elotuzumab in Combination with Lenalidomide and Low-Dose Dexamethasone in High-Risk and/or Stage 2-3 Relapsed and/or Refractory Multiple Myeloma: A Retrospective Subset Analysis of the Phase 2 Study
    Jagannath, Sundar
    Lonial, Sagar
    Jakubowiak, Andrzej J.
    Facon, Thierry
    Vij, Ravi
    Raab, Marc S.
    White, Darrell J.
    Wang, Min-Hui
    Parli, Teresa
    Bartlett, Blake J.
    Singhal, Anil K.
    Richardson, Paul G.
    BLOOD, 2011, 118 (21) : 1697 - 1698
  • [39] Isatuximab in Combination with Lenalidomide and Dexamethasone in Patients with High-Risk Smoldering Multiple Myeloma: Updated Safety Run-in Results from the Randomized Phase 3 Ithaca Study
    Mateos, Maria-Victoria
    Rodriguez Otero, Paula
    Koh, Youngil
    Martinez-Lopez, Joaquin
    Parmar, Gurdeep
    Prince, H. Miles
    Quach, Hang
    Ribas, Paz
    Hermansen, Emil
    Hungria, Vania T. M.
    Besisik, Sevgi Kalayoglu
    Kim, Jin Seok
    Leleu, Xavier
    Peceliunas, Valdas
    Schjesvold, Fredrik
    Sevindik, Omur G.
    Lavrova, Tatiana
    Dubin, Franck
    Devisme, Christine
    Lepine, Lucie
    Mace, Sandrine
    Morisse, Mony
    Ghobrial, Irene
    BLOOD, 2022, 140 : 7317 - 7319
  • [40] Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial
    Rajkumar, S. Vincent
    Jacobus, Susanna
    Callander, Natalie S.
    Fonseca, Rafael
    Vesole, David H.
    Williams, Michael E.
    Abonour, Rafat
    Siegel, David S.
    Katz, Michael
    Greipp, Philip R.
    LANCET ONCOLOGY, 2010, 11 (01): : 29 - 37