The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo

被引：99
|
作者：
Brennan, C [1 ]
Rivas-Plata, K [1 ]
Landis, SC [1 ]
机构：
[1] NINDS, Neural Dev Sect, NIH, Bethesda, MD 20892 USA
来源：
NATURE NEUROSCIENCE | 1999年 / 2卷 / 08期
关键词：
D O I：
10.1038/11158
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To determine the role of the p75 neurotrophin receptor (p75(NTR)) in sympathetic neuron development, we crossed transgenic mice with mutations in p75(NTR), nerve growth factor (NGF) and neurotrophin-3 (NT-3). Neuron number is normal in sympathetic ganglia of adult p75(NTR-/-) mice. Mice heterozygous for a NGF deletion (NGF(+/-)) have 50% fewer sympathetic neurons. In the absence of p75(NTR) (P75(NTR-/-) NGF(+/-)), however, neuron number is restored to wild-type levels. When NT-3 levels are reduced (p75(NTR-/-) NGF(+/-) NT3(+/-)), neuron number decreases compared to p75(NTR-/-) NGF(+/-) NT3(+/+). Thus, without p75(NTR), NT3 substitutes for NGF, suggesting that p75 alters the neurotrophin specificity of TrkA in vivo.
引用
收藏
页码：699 / 705
页数：7
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