Design, synthesis and biological evaluation of 7-azatricyclodecanes: Analogues of cocaine

被引：7
|
作者：
Tamiz, AP [1 ]
Smith, MP [1 ]
Kozikowski, AP [1 ]
机构：
[1] Georgetown Univ, Med Ctr, Inst Cognit & Computat Sci, Drug Discovery Program, Washington, DC 20007 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 03期
关键词：
D O I：
10.1016/S0960-894X(99)00685-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis and biological activity of a series of azatricyclodecane analogues of cocaine are described. All compounds studied in this series exhibit nanomolar potency and good selectivity for the serotonin transporter versus the dopamine transporter. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：297 / 300
页数：4
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