A novel strategy for the synthesis of 2-amino-4,6-diarylnicotinonitrile

被引：20
|
作者：
Shah, Hetal C. [2 ]
Shah, Vaishali H. [2 ]
Desai, Nirmal D. [1 ]
机构：
[1] St Xaviers Coll, Loyola Ctr R&D, Ahmadabad 380009, Gujarat, India
[2] MG Sci Inst, Organ Synth Lab, Ahmadabad 380009, Gujarat, India
来源：
ARKIVOC | 2009年
关键词：
2-Aminonicotinonitrile; tetrazolo[1,5-a]pyridine; chemoselective reduction; liquid-liquid phase transfer catalysis condition; EFFICIENT CHEMOSELECTIVE REDUCTION; HETEROCYCLIC AZIDES; KINASE INHIBITORS; DERIVATIVES; RECEPTOR; AMINES; CONVERSION; ALKYL; ARYL; RIBOFURANOSIDES;
D O I：
10.3998/ark.5550190.0010.209
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and novel strategy has been developed using liquid liquid phase transfer catalysis conditions for the synthesis of 2-amino-4,6-diarylnicotinonitrile and 5,7-diaryltetrazolo[ 1,5-a] pyridine-8-carbonitrile. The former was obtained either by two step process involving azidolysis of 2-chloro-4,6-diarylnicotinonitrile followed by chemoselective reduction of tetrazole moiety while facile one-pot procedure was conveniently carried out from corresponding 2-chloro-4,6-diarylnicotinonitrile.
引用
收藏
页码：76 / 87
页数：12
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