Fit and frailties in proportional hazards regression

被引:4
|
作者
Stare, J [1 ]
O'Quigley, J
机构
[1] Univ Ljubljana, Dept Med Informat, Ljubljana, Slovenia
[2] Inst Curie, Dept Biostat, Paris, France
关键词
Cox model; frailty model; goodness of fit; proportional hazards; partially proportional hazards; time-varying effects;
D O I
10.1002/bimj.200310013
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We exploit a conjectured equivalence between proportional hazards models with frailties and a particular subclass of non proportional hazards models, specifically those with declining effects, to address the question of fit. A goodness of fit test of the proportional hazards assumption against an alternative of declining regression effect is equivalent to a test for the presence of frailties. Such tests are now widely available in standard software. Although a number of tests of the proportional hazards assumption have been developed there is no test that directly formulates the alternative in terms of a non-specified monotonic decline in regression effect and that enables a quantification of this in terms of a simple index. The index we obtain lies between zero and one such that, for any given set of covariates, values of the index close to one indicate that the fit cannot essentially be improved by allowing the possibility of regression effects to decline. Values closer to zero and away from one indicate that the fit can be improved by relaxing the proportional hazards constraint in this particular direction.
引用
收藏
页码:157 / 164
页数:8
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