A cytotoxic diterpene from Alomia myriadenia

被引：22
|
作者：
Zani, CL
Alves, TMA
Queiróz, R
Fontes, ES
Shin, YG
Cordell, GA [1 ]
机构：
[1] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA
[2] FIOCRUZ, Ctr Pesquisas Rene Rachou, Lab Quim Prod Nat, BR-30190002 Belo Horizonte, MG, Brazil
来源：
PHYTOCHEMISTRY | 2000年 / 53卷 / 08期
关键词：
Alomia myriadenia; Asteraceae; 12S,16-dihydroxy-ent-labda-7,13-dien-15,16-olide; diterpene; cytotoxicity;
D O I：
10.1016/S0031-9422(99)00564-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An extract of the aerial palls from Alomia myriadenia Schultz-Bip. ex Baker (Asteracrae) showed significant cytotoxicity against a panel of human cancer cell lines in a screening of extracts from Brazilian Atlantic Forest plant species. Employing a bioassay-linked HPLC-electrospray/MS method, followed by semi-preparative HPLC, the active component was isolated and characterized as a mixture of epimers of the labdane diterpene 12S,16-dihydroxy-ent-labda-7,13-dien-15,16-olide. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：877 / 880
页数：4
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