A review of movement disorders in chemotherapy-induced neurotoxicity

被引:24
|
作者
Wang, Allison B. [1 ,2 ,3 ]
Housley, Stephen N. [4 ]
Flores, Ann Marie [2 ,5 ,6 ]
Kircher, Sheetal M. [6 ,7 ]
Perreault, Eric J. [1 ,3 ,8 ]
Cope, Timothy C. [4 ,9 ,10 ,11 ]
机构
[1] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA
[2] Northwestern Univ, Dept Phys Therapy & Human Movement Sci, Chicago, IL 60611 USA
[3] Shirley Ryan AbilityLab, 355 E Erie St,21st Floor, Chicago, IL 60611 USA
[4] Georgia Inst Technol, Sch Biol Sci, Atlanta, GA 30332 USA
[5] Northwestern Univ, Dept Med Social Sci, Chicago, IL 60611 USA
[6] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Canc Survivorship Inst, Chicago, IL 60611 USA
[7] Northwestern Univ, Dept Hematol & Oncol, Chicago, IL 60611 USA
[8] Northwestern Univ, Dept Phys Med & Rehabil, Chicago, IL 60611 USA
[9] Emory Univ, WH Coulter Dept Biomed Engn, Atlanta, GA 30322 USA
[10] Georgia Inst Technol, Atlanta, GA 30332 USA
[11] Georgia Inst Technol, Integrated Canc Res Ctr, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA
基金
美国国家卫生研究院;
关键词
Cancer; Chemotherapy; Neuropathy; CIPN; Sensorimotor dysfunction; INDUCED PERIPHERAL NEUROPATHY; TAXANE-BASED CHEMOTHERAPY; BREAST-CANCER SURVIVORS; QUALITY-OF-LIFE; POSTURAL CONTROL; FUNCTIONAL IMPAIRMENTS; GAIT PARAMETERS; RISK-FACTORS; BALANCE; FALLS;
D O I
10.1186/s12984-021-00818-2
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Chemotherapy agents used in the standard treatments for many types of cancer are neurotoxic and can lead to lasting sensory and motor symptoms that compromise day-to-day movement functions in cancer survivors. To date, the details of movement disorders associated with chemotherapy are known largely through self-reported symptoms and functional limitations. There are few quantitative studies of specific movement deficits, limiting our understanding of dysfunction, as well as effective assessments and interventions. The aim of this narrative review is to consolidate the current understanding of sensorimotor disabilities based on quantitative measures in cancer survivors who received chemotherapy. We performed literature searches on PubMed and found 32 relevant movement studies. We categorized these studies into three themes based on the movement deficits investigated: (1) balance and postural control; (2) gait function; (3) upper limb function. This literature suggests that cancer survivors have increased postural sway, more conservative gait patterns, and suboptimal hand function compared to healthy individuals. More studies are needed that use objective measures of sensorimotor function to better characterize movement disabilities and investigate the underlying causes, as required for developing targeted assessments and interventions. By updating our understanding of movement impairments in this population, we identify significant gaps in knowledge that will help guide the direction of future research.
引用
收藏
页数:18
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