In vitro metabolism of the neuropeptride antagonist, RWJ-58338, in rat and human hepatic S9 fractions.

被引:0
|
作者
Wu, WN [1 ]
McKown, LA [1 ]
Kordik, CP [1 ]
Reitz, AB [1 ]
机构
[1] Johnson & Johnson Pharmaceut Res & Dev LLC, Spring House, PA 19477 USA
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
160
引用
收藏
页码:80 / 80
页数:1
相关论文
共 50 条
  • [21] Use of human liver and EpiSkin™ S9 subcellular fractions as a screening assays to compare the in vitro hepatic and dermal metabolism of 47 cosmetics-relevant chemicals
    Eilstein, Joan
    Gregoire, Sebastien
    Fabre, Aurelie
    Arbey, Eric
    Genies, Camille
    Duplan, Helene
    Rothe, Helga
    Ellison, Corie
    Cubberley, Richard
    Schepky, Andreas
    Lange, Daniela
    Klaric, Martina
    Hewitt, Nicola J.
    Jacques-Jamin, Carine
    JOURNAL OF APPLIED TOXICOLOGY, 2020, 40 (03) : 416 - 433
  • [22] Screening of the inhibitory effect of xenobiotics on alcohol metabolism using S9 rat liver fractions
    Dias, Catarina
    Testa, Bernard
    Soveral, Graca
    Dias, Mario
    Constantino, Luis
    TOXICOLOGY IN VITRO, 2012, 26 (07) : 1177 - 1180
  • [23] In vitro biotransformation of the new antipsychotic agent, RWJ-46344 in rat hepatic S9 fraction: API-MS/MS/MS identification of metabolites
    Wu, WN
    McKown, LA
    Moyer, MD
    Reitz, AB
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2000, 24 (02) : 307 - 316
  • [24] In Vitro Metabolic Transformation of Pharmaceuticals by Hepatic S9 Fractions from Common Carp (Cyprinus carpio)
    Burkina, Viktoriia
    Sakalli, Sidika
    Pham Thai Giang
    Grabicova, Katerina
    Stanova, Andrea Vojs
    Zamaratskaia, Galia
    Zlabek, Vladimir
    MOLECULES, 2020, 25 (11):
  • [25] Comparison of trout hepatocytes and liver S9 fractions as in vitro models for predicting hepatic clearance in fish
    Fay, Kellie A.
    Fitzsimmons, Patrick N.
    Hoffman, Alex D.
    Nichols, John W.
    ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2017, 36 (02) : 463 - 471
  • [26] A Comparison of In Vitro Metabolic Clearance of Various Regulatory Fish Species Using Hepatic S9 Fractions
    Zercher, Megan
    Coral, Jason A.
    Nabb, Diane
    Powers, Griselda
    Jones, Alan
    Johanning, Karla
    ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2024, 43 (06) : 1390 - 1405
  • [27] Comparison of the metabolism of 10 cosmetics-relevant chemicals in EpiSkin™ S9 subcellular fractions and in vitro human skin explants
    Genies, Camille
    Jacques-Jamin, Carine
    Duplan, Helene
    Rothe, Helga
    Ellison, Corie
    Cubberley, Richard
    Schepky, Andreas
    Lange, Daniela
    Klaric, Martina
    Hewitt, Nicola Jane
    Gregoire, Sebastien
    Arbey, Eric
    Fabre, Aurelie
    Eilstein, Joan
    JOURNAL OF APPLIED TOXICOLOGY, 2020, 40 (02) : 313 - 326
  • [28] EFFECT OF KETOCONAZOLE ON TERFENADINE ENANTIOMERIC METABOLISM IN HUMAN LIVER SLICES, MICROSOMES AND S9 FRACTIONS
    KUANG, TY
    CANTILENA, LR
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1995, 57 (02) : 185 - 185
  • [29] In vitro metabolism of NCX 1000, a NO-derivative of ursodeoxycholic acid by rat, dog, and human liver S9 fraction
    Tocchetti, P
    Morris, G
    Sardina, M
    Santus, G
    DRUG METABOLISM REVIEWS, 2003, 35 : 147 - 147
  • [30] Dataset from proteomic analysis of rat, mouse, and human liver microsomes and S9 fractions
    Golizeh, Makan
    Schneider, Christina
    Ohlund, Leanne B.
    Sleno, Lekha
    DATA IN BRIEF, 2015, 3 : 95 - 98