Synthesis of retro-inverso peptides employing isocyanates of Nα-Fmoc-amino acids/peptide acids catalyzed by DMAP

被引：13

作者：

Venkataramanarao, Rao ^{[1
]}

Sureshbabu, Vommina V. ^{[1
]}

机构：

[1] Bangalore Univ, Dept Studies Chem, Bangalore 560001, Karnataka, India

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 51期

关键词：

EFFICIENT SYNTHESIS; CARBOXYLIC-ACIDS; SYSTEM; AZIDES; AMIDES;

D O I：

10.1016/j.tetlet.2006.10.066

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Goldschmidt-Wick type reaction between isocyanates of N-alpha-Fmoc-amino acids/peptide acids and N-alpha-Boc-/Z-/ Bsmoc-amino acids catalyzed by DMAP leads to the incorporation of a reversed peptide bond. It was found to be a simple, efficient and clean reaction. All the retro-inverso peptides made were obtained as crystalline compounds in 70-92% yields. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：9139 / 9141

页数：3

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