Synthesis and antitumor activity of 1-substituted-2-methyl-5-nitrobenzimidazoles

被引：123
|
作者：
Ramla, Mostafa M. [1 ]
Omar, Mohamed A.
El-Khamry, Abdel-Momen M.
El-Diwani, Hoda I.
机构：
[1] Natl Res Ctr, Chem Nat & Microbial Prod Dept, Cairo, Egypt
[2] Ain Shams Univ, Fac Sci, Dept Chem, Cairo, Egypt
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 21期
关键词：
benzimidazole; thiazoles; triazoles; imidazoles; antitumor activity;
D O I：
10.1016/j.bmc.2006.06.033
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Different substituents were introduced in position 1 of 2-methyl-5(6)-nitro-1H-benzimidazole (2) in order to obtain different side chains having different heterocyclic compounds, for example, thiadiazoles (5-7), tetrazoles (8, 9a, b), triazoles (11-13), thiazoles (14a-e), triazines (10, 16, 17), and imidazoles (18a-c). The antitumor effect of compounds 1, 2, 2a, 4, 5, 7, 8, 9a, 10, 13, 14a, 15, 16, and 18c was studied against breast cancer (MCF7) and compounds 2 [IC50 = 4.52 mu g] and 7 [IC50 = 8.29 mu g] were found to be active. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7324 / 7332
页数：9
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